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Related Concept Videos

Receptor Tyrosine Kinases01:26

Receptor Tyrosine Kinases

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Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...
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mTOR Signaling and Cancer Progression03:03

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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PI3K/mTOR/AKT Signaling Pathway01:22

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The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
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Enzyme-linked Receptors01:00

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Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
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Related Experiment Video

Updated: Mar 30, 2026

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
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Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

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mTORC2 is a tyrosine kinase.

Xuemin Wang1, Christopher G Proud1

  • 1Nutrition and Metabolism Theme, South Australian Health & Medical Research Institute, North Terrace, and University of Adelaide, Adelaide, Australia.

Cell Research
|November 21, 2015
PubMed
Summary

The mammalian target of rapamycin (mTOR) protein kinase regulates insulin-like growth factor 1 receptor signaling. This study reveals mTOR

Area of Science:

  • Cellular signaling pathways
  • Protein kinase function
  • Molecular biology

Background:

  • The mammalian target of rapamycin (mTOR) is a critical protein kinase involved in intracellular signaling.
  • mTOR plays a significant role in various physiological processes and diseases.

Purpose of the Study:

  • To investigate the regulatory role of mTOR in insulin-like growth factor 1 receptor (IGF-1R) signaling.
  • To identify novel enzymatic activities of mTOR.

Main Methods:

  • Investigated mTOR's interaction with IGF-1R signaling pathways.
  • Utilized biochemical assays to identify mTOR's enzymatic activities.

Main Results:

  • Demonstrated that mTOR regulates signaling through the insulin-like growth factor 1 receptor.

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  • Discovered a new enzymatic activity of mTOR: tyrosine phosphorylation of proteins.

    • Conclusions:

    • mTOR possesses a previously unrecognized tyrosine kinase activity.
    • This finding expands our understanding of mTOR's diverse functions in cellular regulation.