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Molecular and epidemiological studies of Porcine rubulavirus infection - an overview
Julieta Sandra Cuevas-Romero1,2, Anne-Lie Blomström3, Mikael Berg3
1Centro Nacional de Investigaciones Disciplinarias en Microbiología Animal, INIFAP, México City, Mexico.
Abstract:
Porcine rubulavirus-La Piedad-Michoacan-Mexico virus (PorPV-LPMV) was identified as the causative agent of a viral disease that emerged spontaneously in Mexican swine in the 1980s. Since the report of the initial outbreak of the disease, only one full-length genome from a strain isolated in 1984 (PorPV-LPMV/1984) has been sequenced; sequence data are scarce from other isolates. The genetic variation of this virus that has spread throughout the main endemic region of Mexico is almost a complete mystery. The development of molecular techniques for improved diagnostics and to investigate the persistence, molecular epidemiology, and the possible reservoirs of PorPV are needed. Together, this will provide greater knowledge regarding the molecular genetic changes and useful data to establish new strategies in the control of this virus in Mexico.
Insights
Porcine rubulavirus-La Piedad-Michoacan-Mexico virus (PorPV-LPMV) genetic variation remains unknown. New molecular techniques are needed for diagnostics and control strategies against this swine virus in Mexico.
Area of Science:
- Veterinary Virology
- Molecular Epidemiology
- Swine Infectious Diseases
Background:
- Porcine rubulavirus-La Piedad-Michoacan-Mexico virus (PorPV-LPMV) emerged in Mexican swine in the 1980s.
- Genetic data for PorPV-LPMV isolates beyond the 1984 strain are scarce.
- The genetic diversity and spread of PorPV-LPMV in Mexico are poorly understood.
Purpose of the Study:
- To highlight the need for molecular techniques to study PorPV-LPMV.
- To investigate the genetic variation, persistence, and molecular epidemiology of PorPV-LPMV.
- To provide data for developing new control strategies against PorPV-LPMV in Mexico.
Main Methods:
- This study is a review and proposal for future research.
- Emphasis on the need for developing and applying molecular techniques.
- Focus on genomic sequencing and epidemiological analysis.
Main Results:
- Currently, only one full-length genome of PorPV-LPMV from 1984 is available.
- Significant gaps exist in understanding the genetic variation of circulating PorPV-LPMV strains.
- The molecular epidemiology and persistence of PorPV-LPMV are largely uncharacterized.
Conclusions:
- Advanced molecular techniques are crucial for understanding PorPV-LPMV.
- Further research is needed to elucidate the genetic diversity and transmission dynamics.
- Developing new diagnostic and control strategies requires comprehensive molecular data.
