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Human mast cells.

A M Dvorak

    Advances in Anatomy, Embryology, and Cell Biology
    |January 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    This review clarifies the ultrastructure of human mast cells, distinguishing their granules from lipid bodies. It details degranulation processes and identifies key morphological differences for accurate identification in tissues.

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    Area of Science:

    • Cell Biology
    • Immunology
    • Histology

    Background:

    • Human mast cells exhibit complex ultrastructural features that vary across different tissues.
    • Distinguishing human mast cells from basophils requires specific ultrastructural criteria.
    • Recent advances allow for the isolation and purification of human mast cells for in-depth study.

    Purpose of the Study:

    • To provide a unified review of human mast cell ultrastructure for accurate identification.
    • To delineate the distinct morphological characteristics of secretory granules and lipid bodies in human mast cells.
    • To detail the ultrastructural changes during mast cell degranulation and recovery.

    Main Methods:

    • Review of existing ultrastructural studies on human mast cells in situ.

    Related Experiment Videos

  • In-depth study of isolated, purified human lung mast cells.
  • Ultrastructural autoradiography and morphometric analysis.

    • Main Results:

    • Established morphological criteria to differentiate human mast cells from basophils.
    • Identified distinct structural, compositional, and dynamic differences between secretory granules and lipid bodies.
    • Demonstrated that lipid bodies, not secretory granules, are the source of arachidonic acid metabolites released during degranulation.
    • Correlated in vitro anaphylactic degranulation kinetics with histamine release, revealing sequential morphological changes including degranulation channels.

    Conclusions:

    • Provides essential ultrastructural information for the identification of human mast cells.
    • Highlights the distinct roles and characteristics of secretory granules and lipid bodies in mast cell function.
    • Elucidates the non-cytotoxic mechanism of mast cell degranulation.