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Updated: Mar 30, 2026

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
Published on: March 6, 2019
Failure to thrive, interstitial lung disease, and progressive digital necrosis with onset in infancy
Justin Chia1, Fehime Kara Eroglu2, Seza Özen2
1Division of Dermatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.
Abstract:
Key teaching points • SAVI is a recently described interferonopathy resulting from constitutive action of STING and up-regulation of IFN-β signaling. • SAVI is characterized by facial erythema with telangiectasia, acral/cold-sensitive tissue ulceration and amputations, and interstitial lung disease. It has overlapping features with Aicardi-Goutières syndrome and familial chilblain lupus. • Traditional immunosuppressive medications and biologic therapies appear to be of limited benefit, but JAK inhibitors may impact disease progression.
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