Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome Annotation and Assembly03:36

Genome Annotation and Assembly

21.5K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
21.5K
Mismatch Repair01:36

Mismatch Repair

45.0K
Overview
45.0K
Mismatch Repair01:20

Mismatch Repair

7.0K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
7.0K
Proofreading01:43

Proofreading

62.0K
Overview
62.0K
Proofreading01:31

Proofreading

9.9K
Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase...
9.9K
Types of Errors: Detection and Minimization01:12

Types of Errors: Detection and Minimization

12.1K
Error is the deviation of the obtained result from the true, expected value or the estimated central value. Errors are expressed in absolute or relative terms.
Absolute error in a measurement is the numerical difference from the true or central value. Relative error is the ratio between absolute error and the true or central value, expressed as a percentage.
Errors can be classified by source, magnitude, and sign. There are three types of errors: systematic, random, and gross.
Systematic or...
12.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

These 'master' proteins protect us from deadly mutations - and could inspire new drugs.

Nature·2026
Same author

The challengers<b>Traversal</b> <i>Maria Popova</i> Farrar, Straus and Giroux, 2026. 608 pp.

Science (New York, N.Y.)·2026
Same author

How the Royal Institution made science a seasonal spectacle.

Nature·2025
Same author

James D Watson: a cautionary tale.

Lancet (London, England)·2025
Same author

Economics Nobel prize won by researchers who showed how science boosts growth.

Nature·2025
Same author

RNA, Not DNA, Is the Key to Life: DNA holds our genetic blueprints, but its cousin, RNA, conducts our daily lives.

Scientific American·2025
Same journal

Publisher Correction: Ultralow-voltage electrochemical organic light-emitting transistors with pinned and wide lateral recombination.

Nature materials·2026
Same journal

High-Chern-number orbital magnetism in twisted rhombohedral graphene.

Nature materials·2026
Same journal

Programming local confinements in crystalline frameworks through reticular chemistry.

Nature materials·2026
Same journal

Single-crystal-like polymer semiconductors via self-templated gradient assembly for ultrahigh charge carrier mobility.

Nature materials·2026
Same journal

Fractional quantum anomalous Hall effect in moiré fractional Chern insulators.

Nature materials·2026
Same journal

Excitons in van der Waals magnetic materials.

Nature materials·2026
See all related articles

Related Experiment Video

Updated: Mar 30, 2026

Simulation of a Scaled Assembly Process with Collaboration of a Robotic Arm and Monitoring through a Vision System for Quality Control
05:47

Simulation of a Scaled Assembly Process with Collaboration of a Robotic Arm and Monitoring through a Vision System for Quality Control

Published on: August 29, 2025

618

Material witness: Correcting errors in self-assembly

Philip Ball

    Nature Materials
    |November 21, 2015
    PubMed
    Summary

    No abstract available in PubMed .

    More Related Videos

    Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis
    11:08

    Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis

    Published on: June 19, 2018

    10.3K
    Protocols for C-Brick DNA Standard Assembly Using Cpf1
    12:03

    Protocols for C-Brick DNA Standard Assembly Using Cpf1

    Published on: June 15, 2017

    8.8K

    Related Experiment Videos

    Last Updated: Mar 30, 2026

    Simulation of a Scaled Assembly Process with Collaboration of a Robotic Arm and Monitoring through a Vision System for Quality Control
    05:47

    Simulation of a Scaled Assembly Process with Collaboration of a Robotic Arm and Monitoring through a Vision System for Quality Control

    Published on: August 29, 2025

    618
    Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis
    11:08

    Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis

    Published on: June 19, 2018

    10.3K
    Protocols for C-Brick DNA Standard Assembly Using Cpf1
    12:03

    Protocols for C-Brick DNA Standard Assembly Using Cpf1

    Published on: June 15, 2017

    8.8K