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Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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[Molecular tumour therapy]

C Michel1, A Neubauer1, A Burchert2

  • 1Klinik für Innere Medizin, Schwerpunkt Hämatologie, Onkologie, Immunologie, Universitätsklinikum Gießen und Marburg, Standort Marburg, und Philipps-Universität, Baldingerstr. 1, 35043, Marburg, Deutschland.

Der Internist
|November 21, 2015
PubMed

Insights

Molecular tumour therapy offers targeted cancer treatment with fewer side effects than traditional chemotherapy. Advances in molecularly designed drugs, like immune checkpoint inhibitors, are transforming oncology but increase healthcare costs.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Context:

  • Molecular tumour therapy has significantly advanced cancer treatment.
  • Key components include kinase inhibitors and monoclonal antibodies.
  • Challenges like therapy resistance persist in current molecular therapies.

Purpose:

  • To review the advancements and challenges in molecular tumour therapy.
  • To highlight the role of molecularly designed drugs in modern oncology.
  • To discuss the impact of these therapies on cancer treatment and healthcare costs.

Summary:

  • Molecular therapies target cancer cells more specifically, aiming for reduced side effects compared to conventional chemotherapy.
  • Despite successes, overcoming tumour resistance remains a significant hurdle.
  • The development of novel molecular drugs, exemplified by immune checkpoint inhibitors, is reshaping cancer care.

Impact:

  • Molecularly designed drugs are revolutionizing oncological therapeutic practices.
  • These targeted approaches offer improved specificity and potentially fewer side effects.
  • The increasing efficacy of molecular therapies is associated with escalating healthcare expenditures.
Keywords:
Antibodies, monoclonalDrug resistance, neoplasmImmunomodulationProtein kinase inhibitorsToxicity

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