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Beyond ion-conduction: Channel-dependent and -independent roles of TRP channels during development and tissue

Kirsten S Vrenken1, Kees Jalink2, Frank N van Leeuwen1

  • 1Laboratory of Pediatric Oncology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, P.O.Box 9101, 6500 HB Nijmegen, The Netherlands.

Biochimica Et Biophysica Acta
|November 21, 2015
PubMed

Insights

Transient receptor potential (TRP) channels are crucial for cell functions like proliferation and survival. This review explores their channel-dependent and -independent roles in development and disease.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Physiology

Background:

  • Transient receptor potential (TRP) channels are ion channels involved in cellular processes.
  • TRP channels play roles in embryonic development, tissue maintenance, and cancer.
  • TRP channel functions can be calcium-dependent and may also occur independently of ion channel activity.

Purpose of the Study:

  • To review the channel-dependent and -independent mechanisms of TRP channels.
  • To discuss the impact of these mechanisms on cellular programs during embryonic development.
  • To explore how TRP channel pathway perturbations contribute to pathologies.

Main Methods:

  • Literature review of existing research on TRP channels.
  • Analysis of studies focusing on TRP channel functions in development and disease.
  • Synthesis of evidence for both channel-dependent and -independent roles.

Main Results:

  • TRP channels mediate essential cellular programs, including proliferation, migration, and survival.
  • Calcium-dependent and channel-independent roles of TRP channels are significant.
  • Dysregulation of TRP channel pathways is linked to various pathologies.

Conclusions:

  • TRP channels are vital for embryonic development and tissue homeostasis.
  • Both ion channel activity and channel-independent functions of TRP channels are critical.
  • Understanding TRP channel mechanisms offers insights into disease pathogenesis.
Keywords:
CalciumEmbryonic developmentEpithelial-mesenchymal transition (EMT)TRP channelsTissue homeostasis

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