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Updated: Mar 30, 2026
05:10
Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
10.3K
Pioneering government-sponsored drug repositioning collaborations: progress and learning
Donald E Frail1,2, Madeleine Brady3,4, K Jane Escott5
1Emerging Innovations Unit, Scientific Partnering &Alliances, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, USA.
Nature Reviews. Drug Discovery
|November 21, 2015
Summary
A novel three-way partnership model for translational research and drug repositioning is advancing by funding new investigations of known compounds in different diseases. This collaborative approach shows promise and is expanding.
Area of Science:
- Biomedical research
- Drug discovery and development
- Translational science
Background:
- A new model for translational research and drug repositioning has been established.
- This model is based on three-way partnerships involving public funders, the pharmaceutical industry, and academic investigators.
Purpose of the Study:
- To discuss the progress of this novel collaborative model.
- To highlight the unique requirements and challenges associated with this translational research approach.
Main Methods:
- Funding new investigations of highly characterized investigational compounds.
- Exploring known mechanisms of action in new disease areas through pioneering initiatives.
- Extending the established model beyond initial pilot programs.
Main Results:
- New investigations have been funded, exploring known mechanisms in novel disease areas.
- The model, initially pioneered by the UK Medical Research Council and the US National Center for Advancing Translational Sciences, has been extended.
Conclusions:
- The three-way partnership model demonstrates progress in translational research and drug repositioning.
- Further discussion is needed on the specific requirements and challenges for the successful implementation and expansion of this model.
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