Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

11.3K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
11.3K
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

109
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
109
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.8K
1.8K
Projectile Motion: Example01:18

Projectile Motion: Example

14.4K
The theory of projectile motion is very useful for players of several sports to improve their performance. For example, a javelin thrower needs to throw their javelin in such a way that it travels as far as possible. The javelin thrower takes a short run-up to increase the initial speed of the javelin. The range of a projectile is at its maximum at a 45° angle so javelin throwers try to angle their throw as close to 45° as possible.
When we speak of the range (R) of a projectile on...
14.4K
Fixed Action Patterns01:06

Fixed Action Patterns

18.1K
A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
18.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Standardized workflow enables reproducibility of drug synergism detection: Results from a multi-center in vitro ring test on complex drug combinations in pancreatic cancer models.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Human organoids: Fit for drug discovery?

Stem cell reports·2026
Same author

Experimental and machine learning-based exploration of repurposed drugs reveals chemical features underlying phospholipidosis.

Patterns (New York, N.Y.)·2026
Same author

The COMBINE pneumonia model: a multicenter study to standardize a mouse pneumonia model with <i>Pseudomonas aeruginosa</i> and <i>Klebsiella pneumoniae</i> for antibiotic development.

Microbiology spectrum·2026
Same author

From algorithms to systems: integrating computation into drug discovery.

Expert opinion on drug discovery·2025
Same author

From library to landscape: integrative annotation workflows for compound libraries in drug repurposing.

Database : the journal of biological databases and curation·2025
Same journal

p38α inhibition restores axonal transport.

Nature reviews. Drug discovery·2026
Same journal

Inflammatory bowel disease-on-a-chip.

Nature reviews. Drug discovery·2026
Same journal

Designing GPCR-targeted miniproteins.

Nature reviews. Drug discovery·2026
Same journal

Pulsatile FXR agonism.

Nature reviews. Drug discovery·2026
Same journal

CRISPR strategy tackles bacterial toxin.

Nature reviews. Drug discovery·2026
Same journal

Time to peak sales: how long is the climb?

Nature reviews. Drug discovery·2026
See all related articles

Related Experiment Videos

Towards a hit for every target.

Steve Rees1, Philip Gribbon2, Karen Birmingham3

  • 1AstraZeneca, Cambridge Science Park, 310 Milton Road, Cambridge CB4 0FZ, UK.

Nature Reviews. Drug Discovery
|November 21, 2015
PubMed
Summary
This summary is machine-generated.

Novel strategies in compound sourcing and management, combined with technological advancements, will significantly enhance the effectiveness of high-throughput screening.

Related Experiment Videos

Area of Science:

  • Drug discovery and development
  • Chemical biology
  • Pharmacology

Background:

  • High-throughput screening (HTS) is a crucial method in drug discovery.
  • Traditional HTS faces challenges in compound management and sourcing.
  • Advancements in technology and collaboration are needed to overcome these limitations.

Purpose of the Study:

  • To explore how technological progress and new collaborative approaches can improve HTS.
  • To highlight the transformative potential of optimized compound sourcing and management in HTS.

Main Methods:

  • Review of current technological advancements relevant to HTS.
  • Analysis of emerging collaborative models for compound sourcing and management.
  • Assessment of the impact of these changes on HTS utility.

Main Results:

  • Technological innovations are streamlining HTS processes.
  • Collaborative strategies are improving the efficiency and scope of compound libraries.
  • The integration of these advancements is poised to revolutionize HTS capabilities.

Conclusions:

  • The synergy between technology and collaboration offers a paradigm shift for HTS.
  • Optimized compound sourcing and management are key to unlocking the full potential of HTS.
  • This transformation promises to accelerate the discovery of novel therapeutic agents.