[Nivolumab, a new hope in non-small cell lung cancer]

Ronan Flippot1, Vincent Fallet2, Benjamin Besse1

  • 1Gustave-Roussy Cancer Campus, département d'oncologie médicale, 94800 Villejuif, France.

Bulletin Du Cancer
|November 21, 2015
PubMed

Insights

Nivolumab immunotherapy offers new hope for lung cancer patients, improving survival in advanced stages. This review details nivolumab

Area of Science:

  • Oncology
  • Immunotherapy
  • Medical Research

Background:

  • Lung cancer is a leading cause of cancer mortality globally.
  • Limited therapeutic options exist for non-small cell lung cancer without targetable mutations.
  • Metastatic lung cancer survival remains poor, often less than two years.

Purpose of the Study:

  • To review the role of nivolumab in lung cancer treatment.
  • To discuss the safety and efficacy of nivolumab based on current clinical data.
  • To guide the integration of nivolumab into clinical practice for optimal patient care.

Main Methods:

  • Systematic review of updated clinical trial data.
  • Analysis of safety and efficacy profiles of nivolumab in lung cancer.
  • Evaluation of nivolumab's impact on patient survival and clinical practice.

Main Results:

  • Nivolumab demonstrates significant potential in improving survival for lung cancer patients.
  • Updated data confirm the safety and efficacy of nivolumab in specific lung cancer settings.
  • Immunotherapy, specifically nivolumab, is poised to change lung cancer treatment paradigms.

Conclusions:

  • Nivolumab represents a significant advancement in lung cancer therapy.
  • Understanding nivolumab's benefits and risks is crucial for effective patient management.
  • The integration of nivolumab is essential for improving long-term outcomes in lung cancer.

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.2K
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

1.5K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.8K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.3K