A comparative histologic study on the healing process after tissue transection. II. Carbon dioxide laser and surgical...

In a previous study we have demonstrated that tissue transection with a carbon dioxide laser produces less carbon and less foreign body reaction than electromicrosurgery. The purpose of this study was to compare the healing process subsequent to transection of the rat uterine horn with carbon dioxide laser and microscissors. Incisions were histologically examined on postoperative days 0, 4, 10, 14, and 21. The following histologic parameters were assessed: scar width; amount of carbon and necrotic debris; number of polymorphonuclear leukocytes, lymphocytes, histiocytes, and giant cells; and extent of edema, exudate, and collagen in the scar. The results show that cutting with a carbon dioxide laser causes significantly more necrosis and hence more extensive foreign body reaction than cutting with microscissors.