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Related Concept Videos

Spinal Nerves: Plexus II01:21

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The plexuses of the lower body include the lumbar, sacral, and coccygeal plexuses, which innervate the abdomen, pelvis, legs, and coccygeal region. These plexuses control the transmission of sensory information and coordinate motor functions of the lower body.
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Spinal nerves are pivotal conduits in the nervous system, bridging the central nervous system (CNS) with the peripheral nervous system (PNS). These nerves enable a complex communication network between the brain, spinal cord, and the rest of the body, facilitating sensory input, motor output, and autonomic functions.
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Nerve plexuses are networks of interlacing nerves that serve as communication hubs to distribute and organize nerve action across various body regions. The nerve plexuses are organized into the cervical plexus located in the neck region, brachial plexus in the shoulder area, lumbar plexus found in the lower back, sacral plexus situated in the pelvis, and coccygeal plexus located in the coccygeal region.
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The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
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Related Experiment Video

Updated: Mar 30, 2026

An In Vivo Murine Sciatic Nerve Model of Perineural Invasion
09:55

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[Sciatic nerve intraneural perineurioma].

Benjamin Bonhomme1, Nicolas Poussange2, Philippe Le Collen3

  • 1Service de pathologie, hôpital Pellegrin, CHU de Bordeaux, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France.

Annales De Pathologie
|November 21, 2015
PubMed
Summary
This summary is machine-generated.

Intraneural perineurioma is a rare, benign nerve tumor causing localized nerve enlargement. This report details a sciatic nerve case, highlighting the characteristic "pseudo-onion bulb" cell pattern in this uncommon condition.

Keywords:
EMAIntraneural perineuriomaNerf sciatiquePérineuriome intraneuralSciatic nerve

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Area of Science:

  • Neurology
  • Oncology
  • Pathology

Background:

  • Intraneural perineurioma is a rare, benign tumor originating from the perineurium.
  • These tumors are known to cause localized nerve hypertrophy and are characterized by a distinctive "pseudo-onion bulb" histological pattern.
  • They represent an uncommon entity within the spectrum of nerve sheath tumors.

Observation:

  • A case of intraneural perineurioma affecting the sciatic nerve is presented.
  • The patient was a 39-year-old individual.
  • The tumor demonstrated the typical histological features of perineural cell proliferation forming "pseudo-onion bulbs".

Findings:

  • The study confirms the occurrence of intraneural perineurioma within the sciatic nerve.
  • Histopathological analysis revealed the characteristic "pseudo-onion bulb" morphology.
  • The tumor was confirmed to be benign, arising from perineural cells.

Implications:

  • This case contributes to the understanding of intraneural perineurioma localization and presentation.
  • It underscores the importance of recognizing this rare tumor in the differential diagnosis of nerve enlargement.
  • Further research may elucidate the specific pathogenesis and optimal management strategies for intraneural perineuriomas.