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Incident asthma and Mycoplasma pneumoniae: A nationwide cohort study

Jun-Jun Yeh1, Yu-Chiao Wang2, Wu-Huei Hsu3

  • 1Department of Chest Medicine and Family Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan; Chia Nan University of Pharmacy and Science, Tainan, Taiwan; Meiho University, Pingtung, Taiwan.

The Journal of Allergy and Clinical Immunology
|November 21, 2015
PubMed
Abstract

Insights

Mycoplasma pneumoniae infection significantly increases the risk of developing asthma, both early-onset and late-onset. This nationwide study confirms a strong link between M. pneumoniae and subsequent asthma diagnosis.

Area of Science:

  • Respiratory Medicine
  • Infectious Diseases
  • Epidemiology

Background:

  • Previous research on Mycoplasma pneumoniae and asthma incidence has yielded inconclusive results.
  • A clear understanding of the association between M. pneumoniae infection and asthma development is needed.

Purpose of the Study:

  • To investigate the relationship between Mycoplasma pneumoniae infection and the incidence of asthma.
  • To clarify the association using a nationwide cohort study.

Main Methods:

  • A nationwide cohort study utilized Taiwan's National Health Insurance Research Database.
  • 1591 patients with M. pneumoniae infection were identified and frequency-matched with 6364 controls.
  • Cox proportional hazards regression analysis determined the adjusted hazard ratio (aHR) for asthma development.

Main Results:

  • Patients with M. pneumoniae infection exhibited a significantly higher risk of incident asthma (aHR = 3.35).
  • This increased risk was observed across various strata, including age, sex, follow-up time, and comorbidities like allergic rhinitis.
  • M. pneumoniae infection was linked to both early-onset (aHR = 2.87) and late-onset asthma (aHR = 3.95).

Conclusions:

  • Mycoplasma pneumoniae infection is closely associated with incident early-onset and late-onset asthma.
  • The link between M. pneumoniae and asthma holds true even in nonatopic individuals.
  • This study provides robust evidence for the role of M. pneumoniae in asthma development.
Keywords:
Mycoplasma pneumoniaeantibioticasthmacohort studysteroid

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