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Updated: Mar 30, 2026

Identification of Post-translational Modifications of Plant Protein Complexes
Published on: February 22, 2014
Acetylation of an NB-LRR Plant Immune-Effector Complex Suppresses Immunity
Jiyoung Lee1, Andrew J Manning1, Donald Wolfgeher1
1Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA.
Abstract:
Modifications of plant immune complexes by secreted pathogen effectors can trigger strong immune responses mediated by the action of nucleotide binding-leucine-rich repeat immune receptors. Although some strains of the pathogen Pseudomonas syringae harbor effectors that individually can trigger immunity, the plant's response may be suppressed by other virulence factors. This work reveals a robust strategy for immune suppression mediated by HopZ3, an effector in the YopJ family of acetyltransferases. The suppressing HopZ3 effector binds to and can acetylate multiple members of the RPM1 immune complex, as well as two P. syringae effectors that together activate the RPM1 complex. These acetylations modify serine, threonine, lysine, and/or histidine residues in the targets. Through HopZ3-mediated acetylation, it is possible that the whole effector-immune complex is inactivated, leading to increased growth of the pathogen.
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