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Immunotherapies for Immune-Mediated Myopathies: A Current Perspective

Merrilee Needham1,2,3, Frank L Mastaglia4,5

  • 1Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, 6150, WA, Australia. Merrilee.Needham@health.wa.gov.au.

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
|November 21, 2015
PubMed

Until recently, the treatment of immune-mediated inflammatory myopathies has largely been empirical with glucocorticoids, steroid-sparing immunosuppressive drugs, and intravenous immunoglobulin. However, a proportion of patients are only partially responsive to these therapies, and there has been a need to consider alternative treatment approaches. In particular, patients with inclusion body myositis are resistant to conventional immunotherapies or show only a transient response, and remain a major challenge. With increasing recognition of the different subtypes of immune-mediated inflammatory myopathies, and improved understanding of their pathogenesis, more targeted treatments are now being trialled. The overall approach to treatment, and novel therapies targeting B cells, T cells, and specific cytokines are discussed in this review.

Keywords:
Immune-mediated myopathyInflammatory myopathyMyositisTreatment

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