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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

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Published on: February 6, 2021

Lysinibacillus spp. Endophthalmitis: a First Reported Case.

Andrew F Perin¹, Sunali Goyal², Eric R Rosenbaum³

¹Department of Ophthalmology, Harvey & Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA AFPerin@uams.edu.

Annals of Clinical and Laboratory Science

|November 21, 2015

Summary

Delayed-onset post-traumatic endophthalmitis (PTE) is rare after eye injuries with foreign bodies. This case highlights a new bacterial cause, Lysinibacillus spp., expanding the known pathogens for delayed PTE.

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Area of Science:

Ophthalmology
Infectious Diseases
Microbiology

Background:

Post-traumatic endophthalmitis (PTE) is a rare complication of open globe injuries.
Intraocular foreign bodies (IOFBs) significantly increase the risk of PTE.
PTE typically presents acutely, with delayed-onset cases being exceptionally uncommon.

Observation:

This report details a unique case of delayed-onset PTE.
The causative agent identified was Lysinibacillus spp., a bacterium previously unreported in ophthalmic literature.
This contrasts with the few existing reports of delayed PTE, which involved different microorganisms.

Findings:

Lysinibacillus spp. can cause delayed-onset post-traumatic endophthalmitis.
This finding expands the spectrum of microbial pathogens associated with delayed PTE.
The case underscores the importance of considering diverse etiologies in delayed presentations of endophthalmitis.

Implications:

Ophthalmologists should consider Lysinibacillus spp. in the differential diagnosis of delayed PTE.
This case may prompt further investigation into the role of Lysinibacillus spp. in ocular infections.
Understanding rare pathogens is crucial for effective management of post-traumatic endophthalmitis.