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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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NONCODE 2016: an informative and valuable data source of long non-coding RNAs.

Yi Zhao1, Hui Li2, Shuangsang Fang2

  • 1School of Medicine, MOE Key Laboratory of Bioinformatics and Bioinformatics Division, Center for Synthetic and System Biology, TNLIST/Department of Automation, Tsinghua University, Beijing 100084, China.

Nucleic Acids Research
|November 21, 2015
PubMed
Summary
This summary is machine-generated.

The NONCODE database now offers comprehensive annotations for over 527,000 non-coding RNAs, including long non-coding RNAs (lncRNAs), across 16 species. This update enhances understanding of lncRNA functions and their links to diseases.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • The NONCODE database serves as a comprehensive resource for non-coding RNA (ncRNA) and long non-coding RNA (lncRNA) annotation.
  • Advances in RNA sequencing and third-generation sequencing have led to a significant increase in identified ncRNA data.
  • Growing experimental evidence is expanding the understanding of lncRNA functions.

Purpose of the Study:

  • To update and expand the NONCODE database with new species and enhanced annotations for non-coding RNAs.
  • To introduce novel features for analyzing lncRNA conservation, disease associations, and data quality.
  • To provide an accessible and up-to-date resource for researchers studying non-coding RNAs.

Main Methods:

  • Integration of data from high-throughput RNA sequencing and third-generation sequencing technologies.
  • Development of new annotation pipelines for lncRNA identification and functional prediction.
  • Curating and incorporating experimental data on lncRNA functions and disease relevance.

Main Results:

  • The NONCODE database now includes 527,336 lncRNAs across 16 species, a substantial increase from previous versions.
  • Specific counts for human (167,150) and mouse (130,558) lncRNAs are now available.
  • New features include conservation annotation, lncRNA-disease relationship mapping, and a quality scoring system for datasets.

Conclusions:

  • The updated NONCODE database provides an unparalleled resource for lncRNA research, facilitating discovery and functional studies.
  • Enhanced features enable researchers to explore lncRNA conservation, disease links, and high-quality data.
  • NONCODE continues to be a vital platform for advancing the field of non-coding RNA biology.