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CAR-T cells are serial killers
Alexander J Davenport1, Misty R Jenkins2, David S Ritchie1
1Cancer Immunology Research; Peter MacCallum Cancer Center , East Melbourne, VIC Australia ; Sir Peter MacCallum Department of Oncology; University of Melbourne , Parkville, VIC Australia ; The ACRF Translational Research Laboratory; Royal Melbourne Hospital , Parkville, VIC Australia.
Abstract:
Chimeric antigen receptor (CAR) T cells have enjoyed unprecedented clinical success against haematological malignancies in recent years. However, several aspects of CAR T cell biology remain unknown. We recently compared CAR and T cell receptor (TCR)-based killing in the same effector cell and showed that CAR T cells can not only efficiently kill single tumor targets, they can also kill multiple tumor targets in a sequential manner. Single and serial killing events were not sustained long term due to CAR down-regulation after 20 hours.