Related Experiment Video
Updated: Mar 30, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
Published on: May 3, 2018
Arterial Stiffness in Children: Pediatric Measurement and Considerations
Jonathan D Savant1, Susan L Furth2, Kevin E C Meyers1
1Division of Nephrology, Department of Pediatrics, The Children's Hospital of Philadelphia, Pa., USA.
Insights
Arterial stiffness measurement in children is feasible and provides valuable cardiovascular insights. This assessment offers more information than standard blood pressure in pediatric chronic diseases.
Area of Science:
- Cardiovascular Physiology
- Pediatric Cardiology
Background:
- Arterial stiffness is a normal part of aging and a predictor of cardiovascular events in adults.
- Research increasingly highlights the significance of arterial stiffness in children.
- Certain chronic conditions can accelerate arterial stiffness.
Purpose of the Study:
- To review the measurement of arterial stiffness in pediatric populations.
- To discuss methodologies and considerations for assessing arterial stiffness in children.
- To examine existing literature on arterial stiffness in children with specific chronic diseases.
Main Methods:
- Focus on carotid-femoral pulse wave velocity and pulse wave analysis.
- Discussion of other arterial stiffness measurement techniques.
- Review of pediatric-specific measurement considerations.
Main Results:
- Arterial stiffness assessment in children is feasible.
- Accurate arterial health information can be obtained under controlled conditions.
- Identified chronic conditions where arterial stiffness is studied in children.
Conclusions:
- Measuring arterial stiffness in children is a viable clinical tool.
- Provides deeper insights into arterial function than brachial artery blood pressure alone.
- Offers valuable data for managing pediatric chronic diseases and cardiovascular risk.
Background:
Arterial stiffness is a natural consequence of aging, accelerated in certain chronic conditions, and predictive of cardiovascular events in adults. Emerging research suggests the importance of arterial stiffness in pediatric populations.
Methods:
There are different indices of arterial stiffness. The present manuscript focuses on carotid-femoral pulse wave velocity and pulse wave analysis, although other methodologies are discussed. Also reviewed are specific measurement considerations for pediatric populations and the literature describing arterial stiffness in children with certain chronic conditions (primary hypertension, obesity, diabetes, chronic kidney disease, hypercholesterolemia, genetic syndromes involving vasculopathy, and solid organ transplant recipients).
Conclusions:
The measurement of arterial stiffness in children is feasible and, under controlled conditions, can give accurate information about the underlying state of the arteries. This potentially adds valuable information about the functionality of the cardiovascular system in children with a variety of chronic diseases well beyond that of the brachial artery blood pressure.
Related Concept Videos
Pre-Procedural Guidelines for Assessing Blood Pressure
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Special considerations while measuring blood pressure
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
Assessment of blood pressure in brachial artery(two-step method)
Assessing Blood pressure in the Leg
Preparation:
Sites for measuring blood pressure
The Brachial Artery: Primary Site for Blood Pressure Measurement

