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Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
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Lipoprotein(a) and Arterial Stiffness Parameters

Alexander Sorokin1, Kazuhiko Kotani2

  • 1Department of Internal Medicine, Kursk State Medical University, Kursk, Russia.

Pulse (Basel, Switzerland)
|November 21, 2015
PubMed

Insights

High levels of lipoprotein(a) [Lp(a)] are linked to increased arterial stiffness. This review of studies suggests a positive association, highlighting the need for further research on cardiovascular outcomes.

Area of Science:

  • Cardiovascular research
  • Atherosclerosis studies
  • Biomarker analysis

Background:

  • Circulating lipoprotein(a) [Lp(a)] and arterial stiffness are key markers in atherosclerotic processes.
  • The relationship between Lp(a) and arterial stiffness concerning cardiovascular outcomes requires further summarization.
  • This review focuses on the existing association between Lp(a) and arterial stiffness parameters.

Purpose of the Study:

  • To review and summarize the existing evidence on the association between lipoprotein(a) and arterial stiffness.
  • To identify the relationship between Lp(a) levels and arterial stiffness parameters in human clinical studies.

Main Methods:

  • A systematic review of human clinical studies published between 1980 and 2015.
  • Search focused on studies measuring arterial stiffness using pulse wave velocity (PWV) and cardio-ankle vascular index (CAVI).
  • Analysis of 4 cross-sectional studies identified through the search criteria.

Main Results:

  • Three of the four included studies reported a positive association between high Lp(a) levels and arterial stiffness.
  • Three studies utilized PWV, and one study used CAVI to assess arterial stiffness.
  • The review identified a limited number of studies (4) specifically investigating this association.

Conclusions:

  • A positive association exists between lipoprotein(a) and arterial stiffness, as measured by PWV and CAVI.
  • Further prospective outcome studies are necessary to confirm these findings.
  • Future research should include simultaneous measurement of Lp(a), its oxidative form, and arterial stiffness parameters (PWV, CAVI).
Abstract

Keywords:
Apolipoprotein(a)Cardio-ankle vascular indexLipoprotein(a)Oxidized lipoprotein(a)Pulse wave velocity

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