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Updated: May 6, 2026

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
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Mitral valve prolapse

T O Cheng1

  • 1Department of Medicine, George Washington University Medical Center, Washington, DC 20037.

Annual Review of Medicine
|January 1, 1989
PubMed

Insights

Mitral valve prolapse (MVP) is common globally and has varied diagnostic criteria. This review examines MVP prevalence, diagnostic challenges, and its serious complications, particularly cardiac arrhythmias.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Mitral valve prolapse (MVP) is a prevalent condition with significant clinical implications.
  • Diagnostic criteria for MVP lack global consensus, complicating accurate identification.
  • MVP is associated with serious complications including chest pain, arrhythmias, and embolism.

Purpose of the Study:

  • To review the global prevalence of mitral valve prolapse.
  • To critically evaluate current diagnostic criteria for MVP.
  • To discuss the pathophysiology of MVP complications, focusing on cardiac arrhythmias.

Main Methods:

  • Literature review of studies on mitral valve prolapse prevalence.
  • Critical analysis of diagnostic criteria for MVP.
  • Review of pathophysiological mechanisms of MVP-associated complications.

Main Results:

  • Mitral valve prolapse exhibits worldwide prevalence, though exact figures vary.
  • Existing diagnostic criteria for MVP present inconsistencies.
  • Cardiac arrhythmias represent a key complication requiring further understanding.

Conclusions:

  • Standardized diagnostic criteria for MVP are needed.
  • Understanding MVP pathophysiology is crucial for managing its complications.
  • Further research into MVP and cardiac arrhythmias is warranted.

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