Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Japanese Version of 26-Item Informant Questionnaire on Cognitive Decline in the Elderly: Development and Validation Study.

Geriatrics & gerontology international·2026
Same author

Pre-Existing Peak-Dose Dyskinesia and Light Body Weight as Predictors of Ropinirole Patch Dose Modification in Parkinson Disease: A Multicenter Retrospective Study.

Clinical neuropharmacology·2026
Same author

Outcomes of Early Versus Later Anticoagulation in Asian Atrial Fibrillation-Related Stroke: ELAN Subgroup Analysis.

Journal of stroke·2026
Same author

Impact of Intracranial Atherosclerosis and Cerebral Small Vessel Disease on Overt Vascular Events During Antithrombotic Therapy.

European journal of neurology·2026
Same author

Impact of Cerebral Small Vessel Disease on Functional Decline: Bleeding With Antithrombotic Therapy 2 Study.

Stroke·2026
Same author

Association of glomerular hyperfiltration with mortality in stroke: an analysis using pooled individual patient data.

European stroke journal·2026

Related Experiment Video

Updated: Mar 29, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.5K

Cerebral Microbleeds: Detection, Associations and Clinical Implications.

Yusuke Yakushiji1

  • 1Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine, Saga, Japan.

Frontiers of Neurology and Neuroscience
|November 21, 2015
PubMed
Summary

Cerebral microbleeds (CMBs) are key imaging markers for small vessel disease, particularly intracerebral hemorrhage (ICH). Their location and associations with aging and hypertension offer insights into underlying causes like hypertensive arteriopathy and cerebral amyloid angiopathy (CAA).

More Related Videos

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images
08:39

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

Published on: November 20, 2015

14.0K
Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats
06:39

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats

Published on: October 17, 2018

7.0K

Related Experiment Videos

Last Updated: Mar 29, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.5K
Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images
08:39

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

Published on: November 20, 2015

14.0K
Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats
06:39

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats

Published on: October 17, 2018

7.0K

Area of Science:

  • Neurology
  • Radiology
  • Pathology

Background:

  • Cerebral microbleeds (CMBs) are increasingly recognized as critical imaging markers for cerebral small vessel disease.
  • Pathologically, CMBs represent hemosiderin-laden macrophages, often associated with intracerebral hemorrhage (ICH).

Purpose of the Study:

  • To review the significance of CMBs as an imaging marker for cerebral small vessel disease.
  • To explore the associations of CMBs with aging, hypertension, and genetic factors.
  • To understand the implications of CMB distribution patterns for identifying underlying pathologies like hypertensive arteriopathy and cerebral amyloid angiopathy (CAA).

Main Methods:

  • Review of paramagnetic-sensitive magnetic resonance imaging findings.
  • Analysis of CMB prevalence across different disease settings, including stroke and dementia.
  • Correlation of CMB distribution patterns (lobar vs. deep/infratentorial) with clinical and pathological factors.

Main Results:

  • CMB prevalence is highest (60%) in intracerebral hemorrhage (ICH) patients.
  • Associations with aging and hypertension support hypertensive arteriopathy and cerebral amyloid angiopathy (CAA) as key pathogeneses.
  • Lobar CMBs often indicate advanced CAA, while deep/infratentorial CMBs are linked to hypertension.

Conclusions:

  • CMBs are valuable imaging biomarkers for understanding cerebral small vessel disease and its underlying causes.
  • CMB patterns can help differentiate between hypertensive arteriopathy and CAA.
  • Further understanding of CMBs may guide therapeutic strategies for ICH and dementia, particularly in CAA.