Related Experiment Video
Updated: Mar 29, 2026
07:00
A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
10.6K
Association of TLR4 (896A/G and 1196C/T) Gene Polymorphisms with Asthma Risk: A Meta-Analysis
Shaojun Li1, Xinming Xie1, Yang Song1
1Department of Respiratory Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China (mainland).
Summary
The Toll-like receptor 4 (TLR4) +1196C/T gene variant may protect against asthma. This meta-analysis found the T allele of TLR4 +1196C/T is associated with reduced asthma risk, particularly in Asian populations.
Area of Science:
- Immunogenetics
- Respiratory Medicine
- Genetic Epidemiology
Background:
- Conflicting data exist regarding the association between Toll-like receptor 4 (TLR4) gene polymorphisms (+896A/G and +1196C/T) and asthma risk.
- Clarifying these genetic associations is crucial for understanding asthma pathogenesis.
Purpose of the Study:
- To conduct a meta-analysis to evaluate the association between TLR4 +896A/G and +1196C/T polymorphisms and asthma risk.
- To provide a comprehensive assessment of existing evidence.
Main Methods:
- Systematic literature search across major databases (PubMed, Embase, Web of Science, CNKI, Wanfang Data).
- Inclusion of 14 studies comprising 2873 asthma cases and 3110 controls.
- Statistical analysis using Odds Ratios (ORs) with 95% Confidence Intervals (CIs) and STATA software.
Main Results:
- The TLR4 +1196C/T polymorphism showed a significant association with reduced asthma risk (T vs. C: OR=0.79, P=0.04).
- Subgroup analysis revealed a significant protective effect in Asians (T vs. C: OR=0.73, P=0.04).
- No significant association was found for the TLR4 +896A/G polymorphism with asthma risk.
Conclusions:
- The T allele of the TLR4 +1196C/T polymorphism may confer a protective effect against asthma development.
- Genetic variations in TLR4 warrant further investigation in asthma research, especially within diverse ethnic groups.
Related Concept Videos
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
68
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
68
01:26Asthma-II: Pathophysiology and Classification
4.8K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.8K
01:29Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
109
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
109
01:29Asthma-I: Introduction
3.7K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.7K
01:19Antiasthma Drugs: Leukotriene Modifiers
2.2K
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
2.2K
01:20Asthma: Pathogenesis and Management
1.7K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.7K