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Updated: Mar 29, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
Serum Thiol/Disulphide Homeostasis in Preeclampsia
Sibel Ozler1, Ozcan Erel2, Efser Oztas1
1a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
Objective:
To determine the serum thiol/disulphide homeostasis in preeclampsia and to investigate the association with clinical parameters.
Methods:
Forty-three pregnant women with preeclampsia and 43 healthy, uncomplicated pregnancies were included in the study. Native thiol, disulphide, and total thiol concentrations were measured by a novel automated method.
Results:
The serum native and total thiol levels were significantly lower in preeclampsia when compared with the healthy group (p < 0.001). There were significant correlations among the homeostatic parameters and preeclampsia.
Conclusion:
Serum thiol/disulphide homeostasis may have a role in the pathogenesis and can be evaluated with the clinical and laboratory findings of preeclampsia.
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