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RabGEF1/Rabex-5 Regulates TrkA-Mediated Neurite Outgrowth and NMDA-Induced Signaling Activation in NGF-Differentiated

See-Ying Tam1, Jennifer N Lilla1, Ching-Cheng Chen1

  • 1Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America.

Plos One
|November 21, 2015
PubMed
Summary

RabGEF1 negatively regulates nerve growth factor (NGF)-induced neuronal differentiation by modulating TrkA receptor signaling and Rac1 activation. It also impacts NMDA receptor signaling in differentiated cells.

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