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Normal values for pancreatic stone protein in different age groups

Luregn J Schlapbach1,2,3, Eric Giannoni4,5, Sven Wellmann6

  • 1Mater Research Institute, Paediatric Critical Care Research Group, University of Queensland, Brisbane, Australia. l.schlapbach@uq.edu.au.

BMC Anesthesiology
|November 22, 2015
PubMed

Insights

Pancreatic stone protein (PSP) levels increase with age from birth through childhood. This study establishes age-specific reference values for PSP, crucial for future sepsis trials.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Clinical Chemistry

Background:

  • Pancreatic stone protein (PSP) is a potential sepsis biomarker in all age groups.
  • Population-based reference values for PSP are currently lacking.
  • Establishing these values is essential for accurate clinical interpretation.

Purpose of the Study:

  • To determine age-specific reference values for pancreatic stone protein (PSP).
  • To establish normal ranges for PSP across different pediatric age groups.
  • To provide a foundation for future clinical trials utilizing PSP as a biomarker.

Main Methods:

  • PSP concentrations were measured using enzyme-linked immunosorbent assay (ELISA).
  • Serum samples from 372 healthy individuals (neonates, children, adults) were analyzed.
  • The adjacent categories method identified significant differences in PSP levels between age groups.

Main Results:

  • PSP levels showed no gender dependency, with a median of 9.2 ng/ml.
  • A significant age-dependent increase in PSP was observed from birth to childhood (p < 0.001).
  • PSP levels were higher on postnatal day three and showed good agreement between capillary and venous samples.

Conclusions:

  • This study successfully established age-specific normal values for PSP.
  • The findings support the use of PSP as a biomarker across different age groups.
  • These reference values will aid in defining cut-offs for future sepsis diagnostic trials.
Abstract

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