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Related Concept Videos

Erythropoiesis01:14

Erythropoiesis

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Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
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Erythropoiesis01:14

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Factors Affecting Erythropoiesis01:24

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The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
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Disorders of Erythrocytes01:27

Disorders of Erythrocytes

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Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
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Hematopoiesis01:21

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Structure and Function of Erythrocytes01:29

Structure and Function of Erythrocytes

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There are between 4.2 and 6 million erythrocytes, also known as red blood cells, in every microliter of blood. These cells are small, flattened biconcave discs with centers that are depressed.
The erythrocyte plasma membrane is associated with proteins such as spectrin, which forms a flexible cytoplasmic meshwork. This meshwork allows erythrocytes to twist, turn, become cup-shaped, and regain their biconcave shape as they pass through narrow capillaries. Additionally, erythrocytes can form...
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Related Experiment Video

Updated: Mar 29, 2026

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes
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Novel methods for studying normal and disordered erythropoiesis.

Jing Liu1, Xu Han1, XiuLi An2

  • 1State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha, 410078, China.

Science China. Life Sciences
|November 22, 2015
PubMed
Summary

New methods enable stage-specific study of erythropoiesis, the process of red blood cell formation. This allows for better understanding of normal and disordered erythropoiesis in various hematological conditions.

Keywords:
erythroblasterythroid progenitorserythropoiesissurface markerstranscriptional profile

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Area of Science:

  • Hematology
  • Cell Biology
  • Developmental Biology

Background:

  • Erythropoiesis, the formation of red blood cells from hematopoietic stem cells, involves distinct developmental stages.
  • Studying erythropoiesis stage-specifically is crucial due to daughter cells differing morphologically and functionally after each mitosis.
  • Previous limitations in isolating erythroid cells at specific developmental stages hindered detailed research.

Purpose of the Study:

  • To review recent advancements in methods for isolating erythroid cells.
  • To highlight the application of these new isolation techniques.
  • To emphasize their utility in studying erythropoiesis in both normal and pathological conditions.

Main Methods:

  • Summarizing recent developments in cell isolation techniques for erythroid cells.
  • Focusing on methods applicable to both murine and human systems.
  • Discussing the application of these methods in research.

Main Results:

  • Development of novel methods for isolating erythroid cells at distinct developmental stages.
  • Successful application of these methods in both mouse and human studies.
  • Enabling detailed analysis of erythropoiesis previously not possible.

Conclusions:

  • Recent advances provide powerful tools for studying erythropoiesis.
  • These methods facilitate the investigation of normal and impaired erythropoiesis.
  • Understanding erythropoiesis is critical for diagnosing and treating hematological disorders.