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[Serum S100β protein reference values in a paediatric population].

M Arroyo Hernández1, J Rodríguez Suárez2, F Álvarez Menéndez3

  • 1Servicio de Pediatría, Hospital San Agustín, Avilés, Asturias, España.

Anales De Pediatria (Barcelona, Spain : 2003)
|November 22, 2015
PubMed
Summary

Serum S100β protein levels are higher in infants and decrease with age. Reference values for S100β in children aged 0-14 years are established, showing stability after age two.

Keywords:
ChildrenNiñosProtein S100βProteína S100βReference valuesValores de referencia

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Area of Science:

  • Pediatric Neurology
  • Biomarker Discovery
  • Clinical Chemistry

Background:

  • S100β protein is a potential biomarker for neurological disorders.
  • Established reference values for S100β exist in adults but not in children.
  • Serum S100β levels in children vary significantly with age.

Purpose of the Study:

  • To establish reference values for serum S100β protein in healthy children aged 0-14 years.
  • To investigate the relationship between serum S100β levels and age in pediatric populations.
  • To determine sex-based differences in serum S100β concentrations in children.

Main Methods:

  • Prospective study involving 257 healthy children.
  • Children categorized into three age groups: under 12 months, 12-24 months, and over 24 months.
  • Serum S100β concentrations measured and analyzed across age groups and sexes.

Main Results:

  • Mean serum S100β concentration was 0.156 μg/l in children aged 0-14 years.
  • Significantly higher S100β levels observed in children under 12 months (0.350 μg/l) compared to older groups.
  • Inverse relationship between age and serum S100β; levels decline with increasing age.
  • No significant sex-based differences in serum S100β levels were found.

Conclusions:

  • Serum S100β concentration is higher in younger children and stabilizes after two years of age.
  • A reliable baseline for serum S100β can be established for children over two years old.
  • Age is a critical factor influencing serum S100β levels in pediatric populations.