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Oxidative Stress: Placenta Function and Dysfunction.

Fan Wu1, Fu-Ju Tian1, Yi Lin1

  • 1Institute of Embryo-Fetal Original Adult Disease, the International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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|November 22, 2015
PubMed
Summary
This summary is machine-generated.

Oxidative stress (OS) in the placenta is crucial for pregnancy signaling and immunity. Imbalances in OS are linked to adverse pregnancy outcomes like preeclampsia.

Keywords:
Antioxidantsimmunoregulationintrauterine growth restrictionpreeclampsiaspontaneous abortion

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Area of Science:

  • Reproductive biology
  • Immunology
  • Biochemistry

Background:

  • The placenta generates oxidative stress (OS) during pregnancy.
  • Uncontrolled OS can impair placental function.
  • Antioxidants are vital for managing OS in the feto-placental unit.

Purpose of the Study:

  • To review the basal functions and regulatory roles of placental OS.
  • To discuss the connection between OS, metabolism, and immunity during pregnancy.
  • To explore the link between OS disorders and adverse pregnancy outcomes.

Main Methods:

  • Literature review of recent studies on placental OS.
  • Analysis of the regulatory roles of OS in placental metabolism and immunity.
  • Examination of the relationship between OS and pregnancy complications.

Main Results:

  • Controlled OS acts as a signaling messenger, regulating gene expression.
  • OS plays a significant role in immune regulation during pregnancy.
  • Oxidative imbalance and immune disturbances are associated with spontaneous abortion, preeclampsia, and intrauterine growth restriction.

Conclusions:

  • Placental OS has essential roles in normal pregnancy metabolism and immunity.
  • Disruptions in OS contribute to pregnancy complications.
  • Further research into OS regulation is critical for managing adverse pregnancy outcomes.