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Related Concept Videos

Cranial Bones: Lateral View01:27

Cranial Bones: Lateral View

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The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
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Cranial Bones: Superior and Posterior View01:14

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The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
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Related Experiment Video

Updated: Mar 29, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
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Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

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Morphometrics, 3D Imaging, and Craniofacial Development.

Benedikt Hallgrimsson1, Christopher J Percival1, Rebecca Green1

  • 1Department of Cell Biology and Anatomy, Alberta Children's Hospital Research Institute, and McCaig Bone and Joint Institute, University of Calgary, Calgary, Alberta, Canada.

Current Topics in Developmental Biology
|November 22, 2015
PubMed
Summary
This summary is machine-generated.

This study explores how geometric morphometrics and volumetric imaging advance the understanding of morphogenesis and birth defects. It highlights methods for quantifying and comparing morphological variation in developmental biology.

Keywords:
CraniofacialImagingMicroCTMorphogenesisMorphometricsMouseOptical Projection TomographyPhenomics

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Area of Science:

  • Developmental Biology
  • Biomedical Imaging
  • Quantitative Morphology

Background:

  • Volumetric imaging and morphometrics are crucial for understanding morphogenesis and structural birth defects.
  • Developmental biology presents unique challenges for morphometrics due to complex questions and diverse imaging data.
  • Understanding the mechanistic basis of morphological variation is essential.

Purpose of the Study:

  • To review methods and theory for applying landmark-based morphometrics to developmental biology, with a focus on craniofacial development.
  • To discuss the theoretical foundations of morphometrics in development.
  • To explore future directions for integrating morphometrics with the genotype-phenotype map.

Main Methods:

  • Review of theoretical foundations of morphometrics in development.
  • Discussion of basic approaches to morphology quantification.
  • Focus on geometric morphometrics and statistical methods for analyzing morphological variation and covariation.

Main Results:

  • Landmark-based morphometrics offers powerful tools for developmental biology.
  • Geometric morphometrics provides methods to quantify and compare morphological variation.
  • The chapter outlines current capabilities and future needs in the field.

Conclusions:

  • Modern morphometric techniques are vital for advancing developmental biology research.
  • Quantitative integration across the genotype-phenotype map requires further development in morphometric approaches.
  • This work provides a foundation for applying advanced morphometrics to study development and variation.