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Recombinant DNA

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Genome Annotation and Assembly

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Related Experiment Video

Updated: Mar 29, 2026

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

GenBank.

Karen Clark¹, Ilene Karsch-Mizrachi¹, David J Lipman¹

¹National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.

Nucleic Acids Research

|November 22, 2015

Summary

This summary is machine-generated.

GenBank is a vital nucleotide sequence database for over 340,000 species. Recent updates improve data submission and reduce redundancy, enhancing its utility for researchers.

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Area of Science:

Bioinformatics
Genomics
Molecular Biology

Background:

GenBank is a primary public repository for nucleotide sequences.
It houses data from over 340,000 formally described species.
Maintaining data integrity and accessibility is crucial for biological research.

Purpose of the Study:

To detail recent developments and ongoing features of the GenBank database.
To highlight improvements in data submission, identification, and redundancy management.
To underscore GenBank's role in integrating diverse biological data.

Main Methods:

GenBank organizes sequence data into 18 divisions.
Unique accession.version identifiers are assigned upon data receipt.
Data submission is facilitated by BankIt and Sequin programs.
Daily data exchange with ENA and DDBJ ensures global coverage.

Main Results:

Implemented a new submitter starting page and a 16S rRNA sequence submission wizard.
Shifted to accession.version identifiers, phasing out GI numbers.
Introduced an Identical Protein Report to mitigate data redundancy.
GenBank data is accessible via Entrez databases (nuccore, nucest, nucgss).

Conclusions:

GenBank continues to evolve, offering enhanced tools for data submission and management.
Its integration with Entrez and BLAST facilitates comprehensive data retrieval and analysis.
Ongoing updates and international collaboration ensure GenBank remains a cornerstone of biological data sharing.