Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

7.5K
We demonstrate how to deploy a real-time psychosis risk calculation and alerting system based on CogStack, an information retrieval and extraction platform for electronic health...
7.5K
Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis07:51

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

8.0K
This article presents a protocol based on Hydra — a web-based system for clinical decision support that integrates a full and detailed set of functionalities and services required by physicians for complete cardiovascular analysis, risk assessment, early diagnosis, treatment, and monitoring over...
8.0K
A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

12.5K
This manuscript describes the Research Prioritization by Affected Communities (RPAC) protocol and findings from its use with women at risk for preterm birth. Using the protocol, women identified and prioritized their unanswered questions about pregnancy, birth and neonatal care aimed at influencing research priority setting by funders and...
12.5K
Watershed Planning within a Quantitative Scenario Analysis Framework12:44

Watershed Planning within a Quantitative Scenario Analysis Framework

8.4K
There is a critical need for tools and methodologies capable of managing aquatic systems in the face of uncertain future conditions. We provide methods for conducting a targeted watershed assessment that enables resource managers to produce landscape-based cumulative effects models for use within a scenario analysis management...
8.4K
High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)11:38

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)

12.7K
The objective of the study was to assess the biological impact of 15 cigarette smoke constituents using a combination of an impedance-based real time cell analyzer and a high-content screening (HCS)-based platform for toxicological assessment in vitro. This study provides information on effective doses, toxicity and modes of action of the tested compounds.
12.7K
Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes17:50

Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes

12.9K
In this candid interview, Anthony A. James explains how mosquito genetics can be exploited to control malaria and dengue transmission. Population replacement strategy, the idea that transgenic mosquitoes can be released into the wild to control disease transmission, is introduced as well as the concept of genetic drive and the design criterion for an effective genetic drive system. The ethical considerations of releasing genetically-modified organisms into the wild are also...
12.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Argininosuccinate Synthase 1 links hepatic urea cycle to whole body lipid metabolism.

bioRxiv : the preprint server for biology·2026
Same author

Hypoxia Impairs CD8<sup>+</sup> T Cell Fitness and Is Associated with a Dysfunctional CD8<sup>+</sup> T Cell State in Pancreatic Cancer.

Cancers·2026
Same author

Analysis of the Frequency and Associated Factors of Skin Toxicity in Patients Receiving Ribociclib-Based Therapy for Metastatic Breast Cancer.

Cancers·2026
Same author

Hypoxia-Induced Fibroblast IL-6 Promotes Immunosuppressive Macrophage Phenotypes in Pancreatic Cancer.

Cells·2026
Same author

A stromal PAI1-tPA axis orchestrates immunosuppression in pancreatic cancer.

Science advances·2026
Same author

Predictive and Prognostic Value of p16 in Head and Neck Squamous Cell Carcinoma Patients Treated with Molecular Targeted Agents or Immune Checkpoint Inhibitors: Subgroup Analysis of the TRIUMPH Study.

Cancer investigation·2026

Related Experiment Video

Updated: Jan 19, 2026

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

7.5K

SnapShot: Hypoxia-Inducible Factors.

Kyoung Eun Lee1, M Celeste Simon1

  • 1Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

Cell
|November 23, 2015
PubMed
Summary

Cells adapt to low oxygen levels using pathways like hypoxia-inducible factors (HIFs). This summary explores recent findings on HIF-dependent adaptations crucial for survival during oxygen deprivation.

Area of Science:

  • Cellular biology
  • Physiology
  • Biochemistry

Background:

  • Molecular oxygen (O2) is vital for mitochondrial ATP production and cellular functions.
  • Maintaining oxygen homeostasis is critical for organism survival.
  • Mammalian cells employ adaptations like hypoxia-inducible factors (HIFs), mTOR, autophagy, and ER stress response during oxygen deprivation.

Purpose of the Study:

  • To summarize recent advancements in understanding hypoxia-inducible factor (HIF)-dependent adaptations to low oxygen levels.
  • To provide an overview of cellular responses to oxygen deprivation.

Main Methods:

  • Review of recent scientific literature on HIF-dependent pathways.
  • Synthesis of findings related to cellular adaptations to hypoxia.

More Related Videos

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
11:38

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC

Published on: May 10, 2016

12.7K
Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes
17:50

Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes

Published on: July 4, 2007

12.9K

Related Experiment Videos

Last Updated: Jan 19, 2026

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

7.5K
High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
11:38

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC

Published on: May 10, 2016

12.7K
Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes
17:50

Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes

Published on: July 4, 2007

12.9K

Main Results:

  • Hypoxia-inducible factors (HIFs) play a central role in mediating cellular responses to low oxygen.
  • Multiple pathways, including mTOR and autophagy, are involved in oxygen homeostasis.
  • Recent reports expand the understanding of HIF-mediated adaptations.

Conclusions:

  • HIF-dependent pathways are crucial for mammalian cell survival under low oxygen conditions.
  • Continued research is expanding our knowledge of these complex adaptive mechanisms.