Related Experiment Video
Updated: Mar 29, 2026
08:53
Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
Published on: August 31, 2016
16.1K
Plasticity of hematopoietic stem cells.
Makio Ogawa1, Amanda C LaRue2, Meenal Mehrotra3
1Medical University of South Carolina, 165 Ashley Ave, MSC 908, Charleston, SC 2C9425, USA.
Best Practice & Research. Clinical Haematology
|November 23, 2015
Summary
Hematopoietic stem cells (HSCs) show remarkable plasticity, potentially regenerating various tissues. Recent studies in mice support the idea that HSCs are pluripotent and can form most cell types in the body.
Area of Science:
- Stem cell biology
- Hematology
- Regenerative medicine
Background:
- Early studies proposed hematopoietic stem cells (HSCs) possess tissue-reconstituting abilities.
- This concept faced controversy and remained largely unexplored for many years.
Purpose of the Study:
- To review evidence supporting HSC plasticity.
- To present findings from single HSC transplantation studies in mice.
Main Methods:
- Review of existing literature on HSC plasticity.
- Preclinical transplantation studies using single HSCs in mouse models.
Main Results:
- Evidence suggests significant plasticity of HSCs.
- Single HSC transplantation studies provide strong support for HSC pluripotency.
Conclusions:
- HSCs are likely pluripotent stem cells.
- HSCs may serve as the origin for a vast majority of cell types in the body.
Related Concept Videos
01:19Multipotency of Hematopoietic Stem Cells
4.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
4.1K
01:01Regulation of Hematopoietic Stem Cells
4.4K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.4K
01:21Hematopoiesis
9.8K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
9.8K
01:21Lineage Commitment
4.6K
Commitment is the process whereby stem cells:
4.6K
01:27Source And Potency Of Stem Cells
6.8K
Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
6.8K
01:20Overview of Hematopoiesis
11.4K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
11.4K