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Updated: Mar 29, 2026

Orthotopic Hind Limb Transplantation in the Mouse
Published on: February 12, 2016
Recent developments in HLA-haploidentical transplantations
Margaret Showel1, Ephraim J Fuchs1
1Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 289 Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21287, USA.
Abstract:
While allogeneic hematopoietic stem cell transplantations have a curative potential, several patients with hematologic malignancies cannot avail themselves of this therapeutic option due to lack of matched donor availability. Although HLA-haploidentical transplantations were previously associated with poor outcomes, recent evidence with use of post transplantation cyclophosphamide indicate improved safety and efficacy. The following paper discusses the most recent developments in this area.
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