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[Clinical implications of basic research in preeclampsia: immunological tolerance]

Jorge Valencia-Ortega, Arturo Zárate, Renata Saucedo

    Ginecologia Y Obstetricia De Mexico
    |November 24, 2015
    PubMed

    Preeclampsia is one of the main causes of maternal and perinatal mortality in the world; however, the pathophysiologic pathways haven't been clearly elucidated. It is thought to result from a breakdown of maternal tolerance to paternal antigens in placenta that start an immune response against the trophoblast inducing a defective placentation and a hipoxic/isquemic environment which in turn triggers a systemic inflamatory response. This review gives an overview of the mechanims involved in maternal tolerance, how these are disrupted in preeclampsia, and how they contribute to the inflamatory response.

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