A Case Report of Post Rabipur (Purified Chick Embryo Rabies Vaccine) Acute Disseminated Encephalomyelitis

Area of Science:

• Neurology
• Immunology
• Vaccinology

Background:

• Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease.
• ADEM typically follows viral infections or vaccinations.
• The incidence of ADEM post-vaccination is low, especially with modern vaccines.

Observation:

• Few cases of ADEM have been linked to pure chick embryo derived rabies vaccine (PCERV).
• This report describes a rare instance of ADEM occurring after PCERV administration.
• The ADEM presentation in this case was delayed post-vaccination.

Findings:

• A rare case of delayed post-vaccinal ADEM is presented.
• The study highlights a potential, albeit infrequent, neurological complication associated with PCERV.
• This case contributes to the understanding of vaccine-induced demyelinating events.

Implications:

• This case underscores the importance of monitoring for rare neurological adverse events following vaccination.
• Further research may be warranted to elucidate the mechanisms behind delayed ADEM post-PCERV.
• Clinicians should be aware of the possibility of delayed ADEM in patients presenting with neurological symptoms after PCERV vaccination.