Related Experiment Video
Updated: Mar 29, 2026
12:00
A Simplified Technique for Producing an Ischemic Wound Model
Published on: May 2, 2012
18.1K
Diabetic Muscle Infarction (Myonecrosis): Underdiagnosed or Underreported?
The Journal of the Association of Physicians of India
|November 24, 2015
Summary
Diabetic muscle infarction is a rare complication affecting individuals with diabetes, particularly those with long-standing disease and poor glycemic control. This case report details a patient with microvascular complications, highlighting the condition
Area of Science:
- Endocrinology
- Pathology
- Radiology
Background:
- Diabetic muscle infarction (DMI) is a rare complication of diabetes mellitus, more frequently observed in Type 1 DM.
- It is associated with longer diabetes duration, poor glycemic control, and microvascular complications.
Observation:
- A 47-year-old male with diabetes and microvascular complications presented with acute, painful swelling of the left thigh muscles.
- Initial investigations revealed mild elevations in CPK and LDH; MRI demonstrated T2 hyperintensities in the affected muscles.
Findings:
- Muscle biopsy confirmed DMI, showing muscle fiber necrosis, inflammatory infiltrates, and characteristic hyalinization of blood vessels with luminal narrowing.
- These pathological findings are indicative of vascular changes associated with diabetic muscle infarction.
Implications:
- This case underscores the rarity of DMI and the diagnostic utility of MRI and muscle biopsy.
- It highlights the potential for poor prognosis and severe complications, emphasizing the need for strict glycemic control and early recognition in diabetic patients.
Related Concept Videos
01:15Diabetes: Symptoms, Diagnosis, and Complications
2.8K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.8K
01:20Pathophysiology of Diabetes
4.4K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.4K
01:22Diabetes Mellitus: Overview and Type I Subtype
6.0K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
6.0K
01:22Diabetes Mellitus: Type 2 and Gestational
5.5K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.5K
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
659
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
659
01:26Peripheral Artery Disease IV: Nursing Management
599
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
599