Related Experiment Video
Updated: Mar 29, 2026

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
Published on: December 22, 2020
Fibroblast Growth Factor-Inducible 14: Multiple Roles in Tumor Metastasis
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China. gangliu.cmitm@xmu.edu.cn.
Fibroblast growth factor-inducible 14 (Fn14) plays a key role in tumor metastasis, influencing processes like cell migration and inflammation. Further research explores its potential as a marker and therapeutic target for cancer spread.
Area of Science:
- Oncology
- Molecular Biology
- Cell Biology
Background:
- Metastasis is the primary cause of cancer mortality, involving complex, multi-step processes.
- Fibroblast growth factor-inducible 14 (Fn14), a TNF receptor family member, regulates cell fate and is implicated in cancer progression.
Purpose of the Study:
- To review recent findings on Fn14's role in tumor metastasis.
- To elucidate Fn14-regulated pathways involved in cancer progression.
- To discuss future applications of Fn14 as a predictive marker and therapeutic target.
Main Methods:
- Literature review of recent studies on Fn14 and tumor metastasis.
- Analysis of molecular pathways regulated by Fn14.
- Discussion of potential clinical applications.
Main Results:
- Fn14 is involved in regulating epithelial-mesenchymal transition, angiogenesis, cytoskeleton dynamics, extracellular matrix degradation, and inflammation.
- Recent studies highlight Fn14's contribution to tumor progression.
- Various Fn14-mediated pathways driving metastasis have been identified.
Conclusions:
- Fn14 is a significant regulator of tumor metastasis.
- Understanding Fn14 pathways offers insights into cancer progression.
- Fn14 shows promise as a biomarker and therapeutic target for suppressing cancer metastasis.
More Related Videos
09:52A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
Published on: September 20, 2016
15:43Experimental Generation of Carcinoma-Associated Fibroblasts CAFs from Human Mammary Fibroblasts
Published on: October 25, 2011
Related Concept Videos
Mitogens and the Cell Cycle
Introduction to Fibroblasts
Regulation of Angiogenesis and Blood Supply
The Tumor Microenvironment
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
TGF - β Signaling Pathway