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Trabectedin for the treatment of breast cancer

Maurizio D'Incalci1, Alberto Zambelli2

  • 1a Department of Oncology , IRCCS - Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, Milan 20156 , Italy.

Expert Opinion on Investigational Drugs
|November 24, 2015
PubMed
Abstract

Insights

Trabectedin shows potential as an anti-cancer drug for metastatic breast cancer (mBC) by affecting transcription and the tumor microenvironment. Further research is needed to confirm its value in treating mBC.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Trabectedin is an approved anti-tumor agent for soft tissue sarcoma and ovarian cancer.
  • It inhibits cancer cell proliferation by regulating transcription and modulates the tumor microenvironment by reducing tumor-associated macrophages (TAMs).

Purpose of the Study:

  • To review preclinical and clinical data on trabectedin's development in metastatic breast cancer (mBC).

Main Methods:

  • Review of existing preclinical and clinical trial data.
  • Analysis of trabectedin's efficacy and mechanism of action in mBC.

Main Results:

  • Trabectedin exhibits potential activity in mBC, possibly due to its effects on DNA repair and tumor microenvironment modulation.
  • The drug's unique mechanism suggests broader applicability in solid malignancies.

Conclusions:

  • Trabectedin demonstrates potential in mBC, warranting further investigation.
  • Its activity in defective DNA-repair machinery and immune modulation supports its role in cancer therapy.
Keywords:
BRCA mutationDNA repairmetastatic breast cancertrabectedin

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