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The pregnane X receptor in tuberculosis therapeutics
Amina I Shehu1, Guangming Li2, Wen Xie1
1a Center for Pharmacogenetics, Department of Pharmaceutical Sciences , School of Pharmacy, University of Pittsburgh , Pittsburgh , PA 15261 , USA.
Expert Opinion on Drug Metabolism & Toxicology
|November 24, 2015
Summary
Tuberculosis (TB) treatment involves rifamycins, which activate the pregnane X receptor (PXR). This activation impacts drug metabolism and resistance, potentially affecting TB therapy outcomes. Further research is crucial to understand PXR's full role.
Area of Science:
- Pharmacology
- Infectious Diseases
- Molecular Biology
Background:
- Tuberculosis (TB) is a leading infectious cause of death globally.
- Rifamycin drugs are essential for TB treatment but activate the human pregnane X receptor (PXR).
- PXR influences drug metabolism, resistance, and immune responses, potentially impacting TB therapy efficacy.
Purpose of the Study:
- To review the role of PXR in modulating the metabolism, efficacy, toxicity, and resistance of anti-TB drugs.
- To explore PXR polymorphisms and their potential influence on TB susceptibility.
Main Methods:
- Literature review focusing on PXR's involvement in TB pharmacotherapy.
- Analysis of PXR's regulatory functions in drug metabolism and resistance.
- Examination of PXR genetic variations and their association with TB.
Main Results:
- PXR activation by rifamycins significantly affects anti-TB drug metabolism and toxicity.
- PXR polymorphisms may influence individual susceptibility and treatment response in TB patients.
- The complex interplay between PXR and TB pharmacotherapy is not fully understood.
Conclusions:
- The multifaceted roles of PXR in TB drug metabolism and toxicity are frequently underestimated.
- Further investigation is required to elucidate the comprehensive impact of PXR activation on TB treatment outcomes.
- Understanding PXR's function is critical for optimizing TB therapeutic strategies.
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