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New concepts in primary fibrositis syndrome
1University of California, Los Angeles.
Comprehensive Therapy
|May 1, 1989
Summary
Fibromyalgia syndrome (PFS) is a painful rheumatologic condition diagnosed by tender points. Research suggests a central nervous system component and subtle tissue lesions may cause PFS symptoms.
Area of Science:
- Rheumatology
- Neuroscience
- Pathology
Background:
- Fibromyalgia syndrome (PFS) is a common, painful rheumatologic disorder affecting all ages.
- PFS is characterized by at least seven tender points and can manifest with depression, sleep disturbances, fatigue, and vestibular issues.
- Distinguishing PFS from similar conditions like CEBV syndrome is crucial due to overlapping symptoms.
Purpose of the Study:
- To explore the potential central nervous system and peripheral tissue components in the etiology of PFS.
- To investigate recent findings on tissue changes in PFS patients.
Main Methods:
- Clinical assessment for tender points.
- Review of recent PFS studies investigating tissue alterations.
Main Results:
- Recent studies indicate potential tissue changes in PFS, including altered microvascular permeability and blood flow.
- Evidence suggests tissue hypoxia and chronic muscle spasm may be present in PFS patients.
- The etiology of PFS remains unknown, but central nervous system involvement and peripheral lesions are hypothesized.
Conclusions:
- PFS may involve both central nervous system and peripheral tissue abnormalities.
- Further research into immunologic factors or connective tissue diseases is warranted for some PFS patients.