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Oligonucleotide-Based Mimetics of Hepatocyte Growth Factor

Ryosuke Ueki¹, Ayaka Ueki¹, Naoto Kanda¹

¹Department of Chemistry and Biotechnology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan).

Angewandte Chemie (International Ed. in English)

|November 24, 2015

Abstract:

Oligonucleotide-based hepatocyte growth factor (HGF) mimetics are described. A DNA aptamer to Met, a cognate receptor for HGF, was shown to induce Met activation when used in dimer form. The most potent aptamer dimer, ss-0, which was composed solely of 100-mer single-stranded DNA, exhibited nanomolar potency. Aptamer ss-0 reproduced HGF-induced cellular behaviors, including migration and proliferation. The present work sheds light on oligonucleotides as a novel chemical entity for the design of growth factor mimetics.

Keywords:

DNA nanotechnology aptamers growth factors receptors signal transduction

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