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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

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Published on: July 19, 2019

Myeloid cell distribution and activity in multiple sclerosis.

Verónica Moliné-Velázquez¹, Virginia Vila-Del Sol², Fernando de Castro³

¹Developmental Neurobiology Group-GNDe, National Hospital for Paraplegics, Finca "La Peraleda", Toledo and Animal Experimental Unit, Scientific Instrumentation Center (CIC), Cartuja Campus, University of Granada, Granada, Spain.

Histology and Histopathology

|November 24, 2015

Summary

This review examines myeloid cells in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It details myeloid cell distribution, markers, and histopathology, including myeloid-derived suppressor cells (MDSCs).

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Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis

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Published on: November 17, 2020

Area of Science:

Neuroimmunology
Cellular Biology

Background:

Multiple sclerosis (MS) is a demyelinating neurological disease characterized by oligodendrocyte loss and myelin sheath destruction.
An overactive immune response, involving various leukocytes, drives MS pathology, leading to the formation of characteristic plaques.
Myeloid cells, including macrophages, dendritic cells (DCs), and neutrophils, play a significant role in the immune response during MS.

Purpose of the Study:

To review the distribution, expression, and available markers for studying myeloid cells in both MS and the EAE animal model.
To explore the histopathology of myeloid cells in MS and EAE.
To discuss the role of myeloid-derived suppressor cells (MDSCs) in immune resolution and their relevance to MS.

Main Methods:

Literature review summarizing existing research on myeloid cells in MS and EAE.
Analysis of myeloid cell distribution, phenotype, and markers in both disease contexts.
Comparison of myeloid cell characteristics between MS patients and the EAE model.

Main Results:

Myeloid cells are key players in MS immunopathology, with distinct roles and distributions.
The EAE model offers insights into MS myeloid cell behavior, though differences exist.
Myeloid-derived suppressor cells (MDSCs) are increasingly recognized for their potential role in immune regulation during demyelinating diseases.

Conclusions:

Understanding myeloid cell dynamics, including MDSCs, is crucial for deciphering MS pathogenesis.
Comparative analysis between MS and EAE highlights conserved and divergent aspects of myeloid cell involvement.
Further research into myeloid cell markers and functions can inform therapeutic strategies for MS.