Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

12.9K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
12.9K
Amyloid Fibrils03:03

Amyloid Fibrils

6.9K
6.9K
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

2.4K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.4K
Subviral Agents01:29

Subviral Agents

748
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
748
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

3.1K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
3.1K
Neural Regulation01:37

Neural Regulation

44.8K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
44.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sound touch elastography for noninvasive assessment of renal fibrosis and chronic kidney disease progression: diagnostic accuracy and histopathological correlation.

Clinical radiology·2025
Same author

MRI features and whole-lesion apparent diffusion coefficient histogram analysis of brain metastasis from non-small cell lung cancer for differentiating epidermal growth factor receptor mutation status.

Clinical radiology·2022
Same author

A review on the Role of Oral Nutritional Supplements in Chronic Obstructive Pulmonary Disease.

The journal of nutrition, health & aging·2022
Same author

Association between serum amyloid A levels and predicting disase severity in COVID-19 patients: a systematic review and meta-analysis.

European review for medical and pharmacological sciences·2021
Same author

One-year outcomes of an osteoporosis liaison services program initiated within a healthcare system.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

The neutrophil to lymphocyte ratio as a novel predictor of asthma and its exacerbation: a systematic review and meta-analysis.

European review for medical and pharmacological sciences·2020

Related Experiment Video

Updated: Mar 29, 2026

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans
12:57

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

Published on: January 8, 2015

16.7K

Prions mediated neurodegenerative disorders.

W-J Huang1, W-W Chen, X Zhang

  • 1Department of Neurology, Xuzhou Central Hospital, Xuzhou, Jiangsu, China. 178508782@qq.com.

European Review for Medical and Pharmacological Sciences
|November 24, 2015
PubMed
Summary

Prions, infectious agents without nucleic acid, cause fatal neurodegenerative diseases by converting normal prion protein (PrPC) into abnormal forms (PrPSc). This review covers prion disease incidence, causes, and spectrum.

More Related Videos

Monitoring Cell-to-cell Transmission of Prion-like Protein Aggregates in Drosophila Melanogaster
10:26

Monitoring Cell-to-cell Transmission of Prion-like Protein Aggregates in Drosophila Melanogaster

Published on: March 12, 2018

8.5K
Protein Misfolding Cyclic Amplification of Prions
10:12

Protein Misfolding Cyclic Amplification of Prions

Published on: November 7, 2012

20.3K

Related Experiment Videos

Last Updated: Mar 29, 2026

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans
12:57

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

Published on: January 8, 2015

16.7K
Monitoring Cell-to-cell Transmission of Prion-like Protein Aggregates in Drosophila Melanogaster
10:26

Monitoring Cell-to-cell Transmission of Prion-like Protein Aggregates in Drosophila Melanogaster

Published on: March 12, 2018

8.5K
Protein Misfolding Cyclic Amplification of Prions
10:12

Protein Misfolding Cyclic Amplification of Prions

Published on: November 7, 2012

20.3K

Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Biochemistry

Background:

  • Prions are unique infectious pathogens lacking nucleic acid.
  • They cause rare, fatal neurodegenerative disorders like Creutzfeldt-Jacob disease (CJD).
  • Prion diseases affect ~1 in 1 million people annually worldwide.

Purpose of the Study:

  • To review recent findings on prion disease pathogenesis.
  • To provide an overview of prion disease incidence, causes, and spectrum.
  • To elucidate the interplay between PrPSc propagation and neurotoxic signaling.

Main Methods:

  • Review of recent scientific literature on prions and prionopathies.
  • Analysis of data on incidence and causes of prion diseases.
  • Synthesis of current understanding of prion protein conformational changes.

Main Results:

  • Prion diseases involve the conversion of normal cellular prion protein (PrPC) to abnormal scrapie prion protein (PrPSc).
  • This conformational change confers protease resistance and leads to PrPSc aggregation in the brain.
  • PrPSc propagation and neurotoxic signaling are implicated in prion pathogenesis.

Conclusions:

  • Prion diseases result from the accumulation of misfolded prion proteins.
  • Understanding prion propagation and neurotoxicity is crucial for unraveling pathogenesis.
  • Further research is needed to fully understand prion-induced neurodegeneration.