Related Experiment Video
Updated: Mar 29, 2026

09:45
Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
Published on: April 12, 2021
9.6K
Update on Molecular Biology of Lung Development--Transcriptomics
1Division of Neonatology and Pediatric Molecular and Personalized Medicine Program, University of Rochester Medical Center, 601 Elmwood Avenue, Box 850, Rochester, NY 14642, USA.
Clinics in Perinatology
|November 24, 2015
Summary
Recent advances in lung developmental biology challenge existing paradigms. These insights offer new perspectives for understanding neonatal chronic lung diseases.
Area of Science:
- Developmental Biology
- Neonatology
- Pulmonology
Background:
- Lung development is a complex process with established paradigms.
- Understanding early lung formation is crucial for addressing neonatal respiratory conditions.
Purpose of the Study:
- To summarize recent significant advances in lung developmental biology.
- To discuss the implications of these advances for neonatal chronic lung diseases.
Main Methods:
- Review of recent scientific literature on lung development.
- Analysis of emerging findings and their impact on current understanding.
Main Results:
- New discoveries challenge existing models of lung development.
- Emerging insights provide a foundation for understanding neonatal lung diseases.
Conclusions:
- Recent advances significantly enhance our fundamental understanding of lung development.
- These findings are highly relevant for the study and treatment of neonatal chronic lung diseases.
Related Concept Videos
Transcription
158.9K
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
158.9K
Transcription
35.5K
Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
35.5K
General Transcription Factors
7.6K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
7.6K
Regulation of Expression Occurs at Multiple Steps
27.1K
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
27.1K
Ribosome Profiling
4.3K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
4.3K

