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The Natural History of Bronchopulmonary Dysplasia: The Case for Primary Prevention

Cindy T McEvoy1, Judy L Aschner2

  • 1Department of Pediatrics, Oregon Health & Science University, 707 SW Gaines Street, CDRC-P, Portland, OR 97239-3098, USA.

Clinics in Perinatology
|November 24, 2015
PubMed

Insights

Bronchopulmonary dysplasia (BPD), a chronic lung disease, primarily affects extremely premature infants. This review covers BPD

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology
  • Developmental Biology

Background:

  • Bronchopulmonary dysplasia (BPD) is the most frequent chronic lung disease in infancy.
  • It predominantly affects extremely premature infants born between 23-28 weeks of gestation.
  • These infants are typically born during the late canalicular/early saccular stages of lung development.

Purpose of the Study:

  • To summarize current knowledge on the life course of BPD.
  • To highlight key articles on the natural history of BPD from birth through adulthood.
  • To advocate for continued focus on primary prevention strategies for BPD.

Main Methods:

  • Literature review of recent and key articles.
  • Synthesis of information on BPD natural history.
  • Emphasis on life course perspective.

Main Results:

  • BPD impacts lung development during critical late canalicular/early saccular stages.
  • The condition's effects extend from infancy through adulthood.
  • Evidence supports the need for ongoing primary prevention efforts.

Conclusions:

  • Understanding the full life course of BPD is crucial.
  • Primary prevention remains a key strategy for managing BPD.
  • Further research and clinical focus on prevention are warranted.

Keywords:
AdolescentAdultBronchopulmonary dysplasiaChildPrematurityPulmonary function

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