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Electromembrane extraction using two separate cells: A new design for simultaneous extraction of acidic and basic

Saeed Nojavan1, Sakine Asadi1

  • 1Faculty of Chemistry, ShahidBeheshti University, Tehran, Iran.

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|November 24, 2015
PubMed
Summary

This study introduces a novel electromembrane extraction (EME) method for simultaneously isolating acidic and basic drugs from samples. The efficient technique successfully extracts multiple drugs, offering a new approach for complex sample analysis.

Keywords:
Acidic and basic drugsElectromembraneSimultaneous extractionTwo separate cellsUrine

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Area of Science:

  • Analytical Chemistry
  • Separation Science
  • Environmental Chemistry

Background:

  • Simultaneous extraction of acidic and basic compounds presents significant analytical challenges.
  • Existing methods often require multiple steps or specialized equipment, limiting efficiency.
  • Developing a streamlined approach for simultaneous extraction is crucial for complex sample matrices.

Purpose of the Study:

  • To develop and validate a novel electromembrane extraction (EME) method for the simultaneous extraction and preconcentration of acidic and basic drugs.
  • To investigate the efficiency of a dual-cell EME system for separating analytes with different chemical properties.
  • To apply the developed method for the quantification of drugs in real-world samples like urine and wastewater.

Main Methods:

  • Utilized a dual-cell electromembrane extraction (EME) setup with separate cells for acidic and basic analytes.
  • Employed 2-ethyl hexanol and 1-octanol as supported liquid membranes for acidic and basic drug extraction, respectively.
  • Applied a potential of 250 V for 20 minutes, optimizing pH conditions in donor and acceptor solutions.

Main Results:

  • Achieved simultaneous extraction of acidic drugs (naproxen, ibuprofen) and a basic drug (ketamine) with recovery rates of 45-54%.
  • Demonstrated good linearity (R² = 0.990-0.996) over a concentration range of 20-1000 ng/mL.
  • Obtained a limit of detection (LOD) of 6.7 ng/mL and reproducibility between 7-12%.

Conclusions:

  • The proposed dual-cell EME method offers an efficient and effective solution for the simultaneous extraction of acidic and basic drugs.
  • The technique is suitable for analyzing drugs in complex biological and environmental samples, achieving satisfactory results.
  • This EME approach provides a valuable tool for trace analysis and sample preparation in pharmaceutical and environmental monitoring.