Related Experiment Video
Updated: Mar 29, 2026
10:17
An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
Published on: November 3, 2010
23.4K
Principle of proportionality in genomic data sharing.
Caroline F Wright1, Matthew E Hurles1, Helen V Firth1,2
1Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Nature Reviews. Genetics
|November 24, 2015
Summary
We propose a proportionality principle for genomic data sharing. This principle balances the amount of data shared against the number of recipients to ensure responsible data dissemination.
Area of Science:
- Genomics
- Bioethics
- Data Science
Background:
- Genomic data is increasingly shared for research.
- Current sharing practices lack a standardized ethical framework.
- Balancing data utility with privacy is crucial.
Purpose of the Study:
- To introduce a novel principle for governing genomic data sharing.
- To establish a framework for ethical and responsible data dissemination.
- To balance data depth with sharing breadth.
Main Methods:
- Conceptual framework development.
- Ethical analysis of data sharing models.
- Proportionality principle formulation.
Main Results:
- A principle of proportionality is proposed for genomic data.
- This principle weighs data depth against sharing breadth.
- It offers a quantitative approach to ethical data sharing.
Conclusions:
- The proportionality principle provides a robust ethical guideline.
- It promotes responsible innovation in genomic research.
- This framework supports secure and effective genomic data sharing.
Related Concept Videos
01:49Hardy-Weinberg Principle
77.4K
Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.
77.4K
02:45The Ratio of X Chromosome to Autosomes
10.1K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
10.1K
03:21Genome Size and the Evolution of New Genes
3.7K
3.7K
03:21Genome Size and the Evolution of New Genes
9.4K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.4K
01:11Genome-wide Association Studies-GWAS
16.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
16.6K
02:54Evolutionary Relationships through Genome Comparisons
7.2K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.2K