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Published on: September 20, 2018
[Pediatric-onset adult type sarcoidosis: A case report]
Yasemin Ozsurekci1, Ali B Cengiz1, Ali Duzova2
1Departamento de Enfermedades Infecciosas Pediátricas, Facultad de Medicina, Universidad Hacettepe.
Insights
Childhood sarcoidosis is a rare multisystem disorder. Diagnosis requires systematic evaluation, as illustrated by a case of a 12-year-old girl with uveitis and hepatosplenomegaly.
Area of Science:
- Pediatrics
- Pulmonology
- Rheumatology
Background:
- Childhood sarcoidosis is a rare multisystem inflammatory disease of unknown cause.
- Its true incidence and prevalence in pediatric populations remain largely unknown.
- Many pediatric cases may be asymptomatic, leading to delayed or missed diagnoses.
Observation:
- A 12-year-old female presented with a two-year history of uveitis and hepatosplenomegaly.
- Chest CT revealed pulmonary nodules and bilateral hilar lymphadenopathy.
- Initial bone marrow and liver biopsies were inconclusive.
Findings:
- Lung biopsy demonstrated non-necrotizing epithelioid granulomas, consistent with sarcoidosis.
- Diagnosis was confirmed by identifying granulomatous inflammation and excluding other potential conditions.
- This case highlights the diagnostic challenges in pediatric sarcoidosis.
Implications:
- Emphasizes the need for thorough diagnostic workups in children with suspected sarcoidosis.
- Suggests that early recognition and diagnosis are crucial for effective management.
- Contributes to understanding the clinical presentation and diagnostic pathway of pediatric sarcoidosis.
Abstract:
Sarcoidosis, a multisystem disorder of unknown etiology that involves multiple organs, is rare in children. The true incidence and prevalence of childhood sarcoidosis is unknown. As in adults, many children with sarcoidosis may be asymptomatic; the disease may remain undiagnosed. A complete and systematic evaluation of the patient is essential for the sarcoidosis diagnosis in children. Here, we describe a case of 12-year-old female who presented with 2 years history of uveitis and hepatosplenomegaly. A chest computerized tomography revealed scattered peripheral pulmonary nodules and bilateral hiliar lymphadenopathy. Bone marrow aspiration and liver biopsy were not diagnostic. A lung biopsy showed non-necrotizing epithelioid cell granulomas. She was diagnosed with sarcoidosis according to demonstration of granulomatous inflammation and the exclusion of confusable entities
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