Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Using hydrogen sulfide to design and develop drugs.

Vincenzo Calderone1, Alma Martelli1, Lara Testai1

  • 1a Dipartimento di Farmacia , Università di Pisa , Pisa , Italy.

Expert Opinion on Drug Discovery
|November 24, 2015
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thiourea-Based H<sub>2</sub>S-Releasing Pramipexole Hybrids as Neuroprotective Agents.

Antioxidants (Basel, Switzerland)·2026
Same author

Simulated Mars Gravity Impairs Intestinal Epithelial Barrier Integrity via Selective Modulation of Tight Junction Components.

Biomolecules·2026
Same author

Global & regional health technology assessment·2026
Same author

Isothiocyanates as Ferroptosis Inducers to Promote Cancer Cell Death.

Phytotherapy research : PTR·2026
Same author

Improving the compatibility of INFOGEST digesta with intestinal epithelial models through post-digestion storage conditions.

Scientific reports·2026
Same author

In Vitro and Ex Vivo Evaluation of a Multi-Target Combination of Plant Extracts and Policosanols: Effects in Mitigating Heart Inflammation and Oxidative Stress.

Foods (Basel, Switzerland)·2026

Hydrogen sulfide (H2S) is a vital gasotransmitter. Modulating the H2S system with novel drug candidates offers promising therapeutic strategies for various diseases, addressing impaired H2S biosynthesis.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Molecular Biology

Background:

  • Hydrogen sulfide (H2S) functions as an endogenous gasotransmitter regulating critical biological processes.
  • Dysregulation of H2S biosynthesis is implicated in the pathogenesis of significant diseases.

Purpose of the Study:

  • To review the biological roles and mechanisms of H2S.
  • To explore the therapeutic potential of modulating the H2S system for disease treatment.

Main Methods:

  • Review of literature on H2S biological functions and mechanisms.
  • Discussion of novel molecules as exogenous H2S sources for therapeutic applications.

Main Results:

  • H2S plays a key role in numerous physiological functions.
Keywords:
GasotransmittersH2S donorsH2S-releasing drug discoveryHydrogen sulfide

Related Experiment Videos

  • Heterogeneous molecules releasing exogenous H2S show promise as drug candidates.

    • Conclusions:

    • Drug development for the H2S system requires careful consideration of H2S release rates, physicochemical properties, and bioavailability.
    • Creating diverse H2S-releasing compounds with varied characteristics is crucial for advancing H2S-based drug discovery.